For an oocyte to generally be All set for fertilization and progress into an embryo, the best set of genes has to be turned on. Namekawa suspected that this pre-programming with the oocyte genome takes place in many phases — the very first one particular starting up across the time a feminine is born. He believed that chromatin remodeling proteins did A great deal of this work, by shifting spools all around.
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This allows the oocytes to pause their development and enter a holding pattern, which lasts into the mouse’s adulthood. In mice lacking PRC1, the oocytes didn’t pause their development; alternatively, they withered and died inside of a thirty day period, leaving the mice permanently infertile.
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Namekawa thinks that in human oocytes, adjustments in these patterns could disrupt the delicate choreography of genes being turned on and off at the right periods — leaving them unprepared for fertilization or development into healthful embryos. Variations in chromatin structure as an oocyte ages might also effects the way that chromosomes segregate through cell division.
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